WebMay 20, 2024 · The cytoplasmic dynein 1 motor (referred to henceforth as dynein) is primarily responsible for microtubule minus-end-directed cargo transport in the cytoplasm of animal cells (Vale, 2003; Vallee et al., 2012).Dynein is a multi-subunit nanomotor built … Web1. The dynein light intermediate chain . 2. The dynein accessory proteins Lis1, Nde and Ndel-1 . This will be achieved by studying and manipulating dynein and accessory protein activity using in ... The overall aim of this project is to determine how cytoplasmic dynein 1’s function as a membrane
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WebOct 31, 2005 · Cytoplasmic dynein is the major microtubule minus end–directed motor protein of the cell; it is involved in many essential cellular processes such as membrane trafficking and mitosis. The cytoplasmic dynein complex is resolved on SDS–polyacrylamide gels into subunit polypeptides of ∼530 (dynein heavy chains), ∼74 … WebHere, we show that loss of dynein-light-chain-1 (DDLC1/LC8) in the cyst cells eliminates bag-of-marbles (bam) expression in spermatogonia, causing gonial cell hyperplasia in …
WebOct 13, 2024 · We describe phenotypic characterization of dli-1, the Caenorhabditis elegans homolog of cytoplasmic dynein light intermediate chain (LIC), a subunit of the cytoplasmic dynein motor complex. Animals homozygous for loss-of-function mutations indli-1 exhibit stochastic failed divisions in late larval cell lineages, resulting in zygotic … WebHere, using mRNA arrays and protein analysis, we show that the dynein subunit, DYNC1LI2 (dynein, cytoplasmic 1 light intermediate chain 2) is downregulated in cystinosis, a lysosomal storage disorder caused by genetic defects in CTNS (cystinosin, lysosomal cystine transporter).
WebNCBI Full Gene Name dynein cytoplasmic 1 light intermediate chain 1; NCBI Gene Aliases 1110053F02Rik, Dncl, Dnclic1, LIC, LIC-1; Primer Type Gene-specific Primers; Add to Compare List. OriGene Technologies. 9620 Medical Center Drive # 200 Rockville, Maryland 20850. United States Phone: 1-888-267-4436 (U.S. only) / 301-340-3188 WebCombinations of intermediate, light intermediate, and light chains make up the rest of the complex. The protein produced from the DYNC1H1 gene is a heavy chain. Other …
WebDuring mitosis, dynein is responsible for positioning the spindle apparatus as well as being localized to the kinetochores to facilitate chromosome movement.The 74.1 antibody recognizes human, mouse, rat, bovine, sheep, Xenopus, porcine, and Drosophila dynein intermediate chain.
WebDynein light chain 1, cytoplasmic. GeneRIFs: Gene References Into Functions. MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans. Data suggest that dynein light chain 1 (DLC-1) acts as a cofactor for multiple ribonucleoprotein complexes, including the ones regulating gene expression during … nothembi mkhwebane songsWebHere, using mRNA arrays and protein analysis, we show that the dynein subunit, DYNC1LI2 (dynein, cytoplasmic 1 light intermediate chain 2) is downregulated in cystinosis, a … nothembi mkhwebane ifihloWebJan 10, 2024 · Aliases for DYNLL1P1 Gene. GeneCards Symbol: DYNLL1P1 2. Dynein Light Chain LC8-Type 1 Pseudogene 1 2 3 5. Dynein, Cytoplasmic, Light Polypeptide 1 Pseudogene 1 2 3. DNCL1P1 3 5. Dynein, Cytoplasmic, Light Polypeptide Pseudogene 3. nothemebuilderWebJun 26, 2013 · We identified Dynein Light Chain 1 (DYNLT1), an integral 14 KDa protein subunit of the large microtubule-based cytoplasmic dynein complex, as an interaction … nothembi ndebele songsWebMar 7, 2002 · The interactions of three subunits of cytoplasmic dynein from Drosophila melanogaster, LC8, Tctex-1, and the N-terminal domain of IC74 (N-IC74, residues 1−289), were characterized in vitro by affinity methods, limited proteolysis, and … nothembi songsWebView Rabbit Polyclonal anti-dynein, cytoplasmic 2, light intermediate chain 1 Antibody (NBP2-82946). Validated Applications: WB. Validated Species: Human. nothemisWebHere, using mRNA arrays and protein analysis, we show that the dynein subunit, DYNC1LI2 (dynein, cytoplasmic 1 light intermediate chain 2) is downregulated in cystinosis, a … nothenios