WebGalectin-7 serum concentration was significantly elevated in women (weeks 10–12 and 17–20) who subsequently developed pre-eclampsia compared to women with healthy pregnancies. Galectin-7 is a promising prospective serum biomarker for pre-eclampsia and likely has important functions in placentation. WebGalectin-7 can also regulate cell growth, through a mechanism that is independent of its pro-apoptotic activity; when added exogenously, it inhibits the growth of neuroblastoma cells …

Cytosolic galectin-7 impairs p53 functions and induces …

WebSep 28, 1999 · In an attempt to isolate new markers of the normal process of epidermal differentiation we previously have cloned a cDNA encoding a novel β-galactoside-binding protein (), galectin-7 (8, 9).Galectin-7 is the … WebNov 3, 2014 · Background Resistance to apoptosis induced by anti-cancer drugs is a major obstacle for the treatment of aggressive forms of breast cancer. Galectin-7 (gal-7) was recently shown to be specifically expressed in basal-like but not in luminal subtypes of human breast cancer. Methods We generated a mutant form of gal-7 (R74S). Arginine … int z byte 128

Identification of Galectin-7 as a crucial metastatic enhancer of

WebFeb 24, 2013 · Ras inhibition induces galectin-7 and reduces galectin-1 expression in NF1-deficient MPNST cells. Ras inhibition by FTS in NF1-deficient MPNST cells inhibits their transformed phenotype both in vitro and in vivo [], reverses their EMT-like phenotype, and alters gene expression [].One of the most significantly upregulated genes in our … Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding. There have been about 15 galectins discovered in … WebOct 14, 2024 · Glycerol is seen in biological systems as an intermediate in lipid metabolism. In recent years, glycerol has been reported to act as a chemical chaperone to correct the conformation of proteins. Here, we investigate the role of glycerol in galectin-7 (Gal-7). The thermal shift and CD assays showed that the thermal stability of Gal-7 increased with … int 割り算 c++